OTOLİN

Otolin-1 (OTOL1) is a collagen-like protein essential for hearing and balance, found specifically in the vertebrate inner ear 
 
. It acts as a scaffold for otoconia (calcium carbonate crystals in the inner ear), binding them together and regulating their formation within the saccule and utricle 
<strong class="Yjhzub" data-sfc-root="c" data-sfc-cb="" data-processed="true">Key Aspects of Otolin-1:</strong>

<ul class="KsbFXc U6u95" data-sfc-root="c" data-sfc-cb="" data-processed="true">
<li class="Z1qcYe" data-sfc-cp="" data-sfc-root="c" data-sfc-cb="" data-hveid="CAMQAQ" data-processed="true"><strong class="Yjhzub" data-sfc-root="c" data-sfc-cb="" data-processed="true">Function:</strong>&nbsp;It serves as an organic matrix scaffold for otoconia, essential for detecting gravity and linear acceleration&nbsp;
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.</li>
<li class="Z1qcYe" data-sfc-cp="" data-sfc-root="c" data-sfc-cb="" data-hveid="CAMQBA" data-processed="true"><strong class="Yjhzub" data-sfc-root="c" data-sfc-cb="" data-processed="true">Location:</strong>&nbsp;Produced by the supporting cells of the sensory epithelium in the vestibular labyrinth and cochlea&nbsp;
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.</li>
<li class="Z1qcYe" data-sfc-cp="" data-sfc-root="c" data-sfc-cb="" data-hveid="CAMQBw" data-processed="true"><strong class="Yjhzub" data-sfc-root="c" data-sfc-cb="" data-processed="true">Structure:</strong>&nbsp;A 65 kDa protein containing collagen-like regions and a C-terminal C1q-like domain, forming large oligomeric structures&nbsp;.</li>
<li class="Z1qcYe" data-sfc-cp="" data-sfc-root="c" data-sfc-cb="" data-hveid="CAMQCg" data-processed="true"><strong class="Yjhzub" data-sfc-root="c" data-sfc-cb="" data-processed="true">Interaction:</strong>&nbsp;Works alongside other proteins like&nbsp;Otoconin-90&nbsp;to modulate the growth of calcium crystal</li>
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